- 专利标题： Autotaxin inhibitory compounds
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申请号： US16826046申请日： 2020-03-20
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公开(公告)号： US11453666B2公开(公告)日： 2022-09-27
- 发明人: Martin Lee Stockley , Ellen Catherine Macdonald , Pritom Shah , Allan Jordan , James Hitchin , Niall Hamilton
- 申请人： Cancer Research Technology Limited
- 申请人地址： GB London
- 专利权人： Cancer Research Technology Limited
- 当前专利权人： Cancer Research Technology Limited
- 当前专利权人地址： GB London
- 代理机构： Mintz Levin Cohn Ferris Glovsky and Popeo, P.C.
- 优先权： GB1502020 20150206
- 主分类号： A61P1/00
- IPC分类号： A61P1/00 ; A61P1/16 ; A61P29/00 ; A61P31/20 ; A61P31/14 ; A61P31/12 ; A61P3/10 ; A61P7/12 ; A61P17/00 ; A61P17/04 ; A61P17/02 ; A61P35/00 ; A61P35/02 ; A61P7/04 ; A61P7/02 ; A61P13/02 ; A61P13/12 ; A61P9/12 ; A61P9/00 ; A61P43/00 ; A61P19/04 ; A61K31/5025 ; A61K31/444 ; A61K31/4545 ; A61K31/5377 ; A61K31/404 ; A61K31/551 ; A61K31/55 ; A61K31/496 ; A61K31/4184 ; A61K45/06 ; C07D235/02 ; C07D471/04 ; A61K31/437
摘要：
The present invention relates to compounds of formula I wherein A1, A2, A3, R1, R2, R3, R4, R5, R6, L, Ar and Q are each as defined herein. The compounds of the present invention are inhibitors of autotaxin (ATX) enzyme activity. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions (e.g. fibrosis) in which ATX activity is implicated.
公开/授权文献
- US20200283435A1 Autotaxin Inhibitory Compunds 公开/授权日：2020-09-10
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