Systems and methods for unified application-level backup and restore using heterogeneous cloud-based backup service providers. An application programming interface is configured to process both data level replication operations as well as application-level operations that are executed to carry out high-level commands between a virtualized computing environment and any one or more of the heterogeneous cloud-based backup service providers. The API receives commands from applications in the virtualized computing environment. The API processes commands from the applications so as to facilitate replication of data to selected one or more cloud-based backup service providers. The commands perform data level replication operations as well as application-level operations for storing content to the cloud-based service provider. After a failure event and/or upon receipt of a restore command, the API initiates application-level operations that restore the application and its constituent entities. The data state is restored by the API using data level restore operations.