An intelligent multiple antenna and radio interconnect optimizer includes an antenna port suitable for a connection to an antenna, a radio port suitable for a connection to a radio, a machine readable identifier coupled to one of the antenna port, the radio port and a combination thereof, the machine readable identifier suitable to identify a feature in each of a radio being connected to the radio port and an antenna being connected to the antenna port, a radio frequency (RF) switch configured to connect the antenna port with the radio port in a response to a connection permission signal from the machine readable identifier when the feature in the radio matches the feature in the antenna, and a controller configured to receive antenna and radio port location inputs from the machine readable identifier, and control operation of the RF switch.