System and method for digitized digit symbol substitution test (DSST) are disclosed. In an example, a display area of a digitized DSST device is partitioned into multiple bins. Further, a series of number symbol pairs is displayed as a lookup table on top of the display, termed as a lookup area. Furthermore, a question and answer (QA) pair corresponding to the series of number symbol pairs to an examinee in multiple trials. In addition, feature values for the QA pair are computed in each of the multiple bins in the trials, wherein the feature values comprise a response time and an accuracy of response by the examinee. Moreover, probabilities of the feature values are determined in each of the multiple bins. Also, an entropy value based on the probabilities of the feature values is computed in each of the multiple bins providing information on distribution.