Embodiments of the present invention pertain to antimicrobial glass compositions, glasses, and articles. The articles include a glass, which may include a glass phase and a cuprite phase. In other embodiments, the glasses include a plurality of Cu1+ ions, a degradable phase including B2O3, P2O5 and K2O, and a durable phase including SiO2. Other embodiments include glasses having a plurality of Cu1+ ions disposed on the surface of the glass and in the glass network and/or the glass matrix. The article may also include a polymer. The glasses and articles disclosed herein exhibit a 2 log reduction or greater in a concentration of at least one of Staphylococcus aureus, Enterobacter aerogenes, Pseudomonas aeruginosa bacteria, Methicillin Resistant Staphylococcus aureus, and E. coli, under the EPA Test Method for Efficacy of Copper Alloy as a Sanitizer testing condition and under Modified JIS Z 2801 for Bacteria testing conditions.