Invention Grant
- Patent Title: Adhesion-preventing composition
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Application No.: US16316097Application Date: 2017-07-13
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Publication No.: US11464597B2Publication Date: 2022-10-11
- Inventor: Taichi Ito , Seiichi Ohta , Norihiro Kokudo , Mitsuko Isaji , Satoshi Shimizu
- Applicant: Mochida Pharmaceutical Co., Ltd. , The University of Tokyo
- Applicant Address: JP Tokyo; JP Tokyo
- Assignee: Mochida Pharmaceutical Co., Ltd.,The University of Tokyo
- Current Assignee: Mochida Pharmaceutical Co., Ltd.,The University of Tokyo
- Current Assignee Address: JP Tokyo; JP Tokyo
- Agency: Foley & Lardner LLP
- Priority: JPJP2016-138666 20160713
- International Application: PCT/JP2017/025614 WO 20170713
- International Announcement: WO2018/012605 WO 20180118
- Main IPC: A61B90/00
- IPC: A61B90/00 ; A61L31/14 ; A61L31/12 ; A61L31/04

Abstract:
[Problem] An adhesion-preventing material having a high adhesion-preventing effect has been demanded.
[Solution] An adhesion-preventing material including a sterilized biocompatible sponge-like laminate, wherein the sponge-like laminate comprises a sponge-like first layer and a sponge-like second layer each of which is at least partially crosslinked with a curing agent and comprises a low-endotoxin alginic acid monovalent metal salt, the alginic acid monovalent metal salt in the first layer has a weight average molecular weight of 10,000 to 2,000,000, the alginic acid monovalent metal salt in the second layer has a weight average molecular weight of 1,000 to 1,000,000, the weight average molecular weights are measured by a GPC-MALS method after a decrosslinking treatment, and the weight average molecular weight of the alginic acid monovalent metal salt in the first layer is higher than that in the second layer.
[Solution] An adhesion-preventing material including a sterilized biocompatible sponge-like laminate, wherein the sponge-like laminate comprises a sponge-like first layer and a sponge-like second layer each of which is at least partially crosslinked with a curing agent and comprises a low-endotoxin alginic acid monovalent metal salt, the alginic acid monovalent metal salt in the first layer has a weight average molecular weight of 10,000 to 2,000,000, the alginic acid monovalent metal salt in the second layer has a weight average molecular weight of 1,000 to 1,000,000, the weight average molecular weights are measured by a GPC-MALS method after a decrosslinking treatment, and the weight average molecular weight of the alginic acid monovalent metal salt in the first layer is higher than that in the second layer.
Public/Granted literature
- US20190209260A1 ADHESION-PREVENTING COMPOSITION Public/Granted day:2019-07-11
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