Methods and systems for injection of tokens or certificates for managed application communication are described. A computing device may intercept a request from an application executable on the computing device, the request being to access a remote resource. The computing device may modify future network communications between the computing device and the remote resource to include a token or a client certificate, where the token or the client certificate is an identifier that enables the future network communications to be routed to the remote resource for a given computing session without use of data from the remote resource or data indicative of a connection of the remote resource in which to receive the future network communications. The computing device may send the future network communications to the remote resource to enable action to be taken on behalf of the computing device in response to receipt of the future network communications.