- 专利标题: Small molecule modulators of the BTB domain of Keap1
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申请号: US16955403申请日: 2018-12-20
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公开(公告)号: US11479539B2公开(公告)日: 2022-10-25
- 发明人: Johan Bartholomeus , Roland Bürli , Rebecca Jarvis , Shawn Johnstone , Thor Ostenfeld , Ina Terstiege , Massimiliano Travagli , Stephane Turcotte
- 申请人: MedImmune Limited
- 申请人地址: GB Cambridge
- 专利权人: MedImmune Limited
- 当前专利权人: MedImmune Limited
- 当前专利权人地址: GB Cambridge
- 国际申请: PCT/EP2018/086436 WO 20181220
- 国际公布: WO2019/122265 WO 20190627
- 主分类号: C07D401/04
- IPC分类号: C07D401/04 ; C07D213/61 ; C07D417/04
摘要:
The present application relates to compounds of formula (I′) or formula (I), such as formula (Ia), and their pharmaceutical compositions/preparations. This application further relates to methods of treating or preventing neurodegenerative disorders, such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington disease (HD) and other CAG-triplet repeat (or polyglutamine) diseases, amyotrophic lateral sclerosis (ALS; Lou Gehrig's disease), diffuse Lewy body disease, chorea-acanthocytosis, primary lateral sclerosis, multiple sclerosis (MS), frontotemporal dementia, Friedreich's ataxia, acute head injury, and epilepsy (repression of microglia activation).
公开/授权文献
- US20210094931A1 SMALL MOLECULE MODULATORS OF THE BTB DOMAIN OF KEAP1 公开/授权日:2021-04-01