A surgical instrument system comprising an elongate shaft is disclosed. The elongate shaft comprises a proximal end, a distal end, a proximal region, a central region, and a distal region. The proximal region comprises a first diameter. The central region comprises a second diameter. The distal region comprises a third diameter. The first diameter is different than the second diameter, and the second diameter is different than the third diameter. The proximal region defines a central longitudinal axis and the central region is centered along the central longitudinal axis. The distal region is laterally offset with respect to the central longitudinal axis.