- 专利标题： Compounds useful as inhibitors of ATR kinase
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申请号： US16994968申请日： 2020-08-17
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公开(公告)号： US11485739B2公开(公告)日： 2022-11-01
- 发明人: Jean-Damien Charrier , Christopher John Davis , Damien Fraysse , Gorka Etxebarria I Jardi , Simon Pegg , Francoise Pierard , Joanne Pinder , John Studley , Carl Zwicker , Tapan Sanghvi , Michael Waldo , Ales Medek , David Matthew Shaw , Maninder Panesar , Yuegang Zhang , Naziha Alem
- 申请人： Vertex Pharmaceuticals Incorporated
- 申请人地址： US MA Boston
- 专利权人： Vertex Pharmaceuticals Incorporated
- 当前专利权人： Vertex Pharmaceuticals Incorporated
- 当前专利权人地址： US MA Boston
- 代理机构： Dechert LLP
- 代理商 Andrea L. C. Reid; Danielle M. Nihan
- 主分类号： C07D487/04
- IPC分类号： C07D487/04 ; C07C45/00 ; C07C45/63 ; C07B59/00 ; A61K31/519
摘要：
The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and solid forms of the compounds of this invention.
The compounds of this invention have formula I-A or I-B: wherein the variables are as defined herein.
The compounds of this invention have formula I-A or I-B: wherein the variables are as defined herein.
公开/授权文献
- US20210032255A1 COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE 公开/授权日：2021-02-04
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