Invention Grant
- Patent Title: 3′-UTR sequences for stabilization of RNA
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Application No.: US15763709Application Date: 2016-10-05
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Publication No.: US11492628B2Publication Date: 2022-11-08
- Inventor: Alexandra Orlandini Von Niessen , Stephanie Fesser , Britta Vallazza , Tim Beissert , Andreas Kuhn , Ugur Sahin , Marco Alexander Poleganov
- Applicant: BioNTech SE , TRON—Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg-Universität Mainz gGmbH
- Applicant Address: DE Mainz; DE Mainz
- Assignee: BioNTech SE,TRON—Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg-Universität Mainz gGmbH
- Current Assignee: BioNTech SE,TRON—Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg-Universität Mainz gGmbH
- Current Assignee Address: DE Mainz; DE Mainz
- Agency: Choate, Hall & Stewart LLP
- Agent Brenda Herschbach Jarrell; Janet M. Tse
- Priority: EPPCT/EP2015/073814 20161005
- International Application: PCT/EP2016/073814 WO 20161005
- International Announcement: WO2017/060314 WO 20170413
- Main IPC: C12N15/67
- IPC: C12N15/67 ; A47B3/00 ; A47B13/02 ; A47B33/00 ; A47B43/00 ; A47B77/02 ; A47B77/06 ; A47B77/08 ; A47B77/16 ; A47B77/18 ; A47B95/00 ; A47C4/00 ; A47C4/08 ; A47C7/00 ; A47K3/28 ; B60B33/00 ; E04H1/12 ; F16C11/04 ; C12N5/0735 ; C12N15/113 ; C12N15/90
Abstract:
The present invention relates to stabilization of RNA, in particular mRNA, and an increase in mRNA translation. The present invention particularly relates to a modification of RNA, in particular in vitro-transcribed RNA, resulting in increased transcript stability and/or translation efficiency. According to the invention, it was demonstrated that certain sequences in the 3′-untranslated region (UTR) of an RNA molecule improve stability and translation efficiency.
Public/Granted literature
- US20190071682A1 3'-UTR Sequences for Stabilization of RNA Public/Granted day:2019-03-07
Information query
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