A uniform enclave interface is provided for creating and operating enclaves across multiple different types of backends and system configurations. For instance, an enclave manager may be created in an untrusted environment of a host computing device. The enclave manager may include instructions for creating one or more enclaves. An enclave may be generated in memory of the host computing device using the enclave manager. One or more enclave clients of the enclave may be generated by the enclave manager such that the enclave clients configured to provide one or more entry points into the enclave. One or more trusted application instances may be created in the enclave.