The present disclosure provides a panel display optimization method, a display panel, and a storage medium. The panel display optimization method includes a region acquisition step, an adjustment step, and a high-low gray level step. The present disclosure is used to make processing coefficients of high-low gray levels of pixels to be processed having farther boundaries be greater according to distances from the pixels to be processed to the boundaries of a first pixel region, a second pixel region, and a third pixel region, that is, according to forward transitional spaces and backward transitional spaces to adjust the processing coefficients of the high-low gray levels. This further reduces graininess of the panel and improves visual quality of the panel after performing high-low gray level processing on adjusted pixels.