Invention Grant
- Patent Title: Macrocyclic spiroethers as Mcl-1 inhibitors
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Application No.: US17049100Application Date: 2020-01-17
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Publication No.: US11498928B2Publication Date: 2022-11-15
- Inventor: Jianyong Chen , Yunlong Zhou , Guozhi Tang , Chengzhe Wu , Leilei Zhao , Lingling Jiao , Binghua Sheng , Shaomeng Wang , Chao-Yie Yang , Hao Chen , Wenliang Hu , Yu Jing
- Applicant: ASCENTAGE PHARMA (SUZHOU) CO., LTD. , THE REGENTS OF THE UNIVERSITY OF MICHIGAN , ASCENTAGE PHARMA GROUP CORP LIMITED
- Applicant Address: CN Suzhou; US MI Ann Arbor; CN Hong Kong
- Assignee: ASCENTAGE PHARMA (SUZHOU) CO., LTD.,THE REGENTS OF THE UNIVERSITY OF MICHIGAN,ASCENTAGE PHARMA GROUP CORP LIMITED
- Current Assignee: ASCENTAGE PHARMA (SUZHOU) CO., LTD.,THE REGENTS OF THE UNIVERSITY OF MICHIGAN,ASCENTAGE PHARMA GROUP CORP LIMITED
- Current Assignee Address: CN Suzhou; US MI Ann Arbor; CN Hong Kong
- Agency: Marshall, Gerstein & Borun LLP
- Priority: WOPCT/CN2019/072347 20190118,WOPCT/CN2019/099673 20190807
- International Application: PCT/CN2020/072565 WO 20200117
- International Announcement: WO2020/147802 WO 20200723
- Main IPC: C07D513/20
- IPC: C07D513/20 ; C07D515/20 ; C07D498/08 ; A61K31/553 ; A61P35/00 ; C07D513/10 ; C07D519/00
Abstract:
Provided are compounds represented by Formula (I-A) and the pharmaceutically acceptable salts and solvates thereof, wherein R8, R9a, R9b, R9c, R9d, X, Y, Z, Z1, W, and (aa) are as defined as set forth in the specification. Provided are also compounds of Formula (I-A) for use to treat a condition or disorder responsive to Mcl-1 inhibition such as cancer.
Public/Granted literature
- US20210340158A1 MACROCYCLIC SPIROETHERS AS MCL-1 INHIBITORS Public/Granted day:2021-11-04
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