Invention Grant
- Patent Title: 8-phenyl-isoquinolines and pharmaceutical composition thereof used in the treatment of irritable bowel syndrome
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Application No.: US16490070Application Date: 2018-03-02
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Publication No.: US11505529B2Publication Date: 2022-11-22
- Inventor: Ling-Wei Hsin , Linda Chia-Hui Yu , Tsung-Chun Lee
- Applicant: Linda Chia-Hui Yu
- Applicant Address: TW Taipei
- Assignee: Linda Chia-Hui Yu
- Current Assignee: Linda Chia-Hui Yu
- Current Assignee Address: TW Taipei
- Agent Hannah M. Tien
- International Application: PCT/CA2018/000043 WO 20180302
- International Announcement: WO2018/157233 WO 20180907
- Main IPC: C07D217/04
- IPC: C07D217/04 ; A61P1/00 ; C07D401/06
Abstract:
A series of 8-phenyl-isoquinoline derivatives (I) exhibit high binding affinity to 5-HT7 receptor (5-HT7R) and demonstrate potent antinociceptive activity in two animal models for Irritable Bowel Syndrome (IBS) by intraperitoneal injection (i.p.) or by oral administration (p.o.). These 5-HT7 receptor antagonists are a new class of therapeutic agents for the treatment of IBS.
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