In various examples, a deep neural network (DNN) is trained for sensor blindness detection using a region and context-based approach. Using sensor data, the DNN may compute locations of blindness or compromised visibility regions as well as associated blindness classifications and/or blindness attributes associated therewith. In addition, the DNN may predict a usability of each instance of the sensor data for performing one or more operations—such as operations associated with semi-autonomous or autonomous driving. The combination of the outputs of the DNN may be used to filter out instances of the sensor data—or to filter out portions of instances of the sensor data determined to be compromised—that may lead to inaccurate or ineffective results for the one or more operations of the system.