A dressing for treating a tissue site, particularly an abdominal or peritoneal site, is disclosed. In some embodiments, the dressing may comprise a tissue interface formed from a first layer of a liquid-impermeable material and a plurality of manifolding bubbles formed as part of the first layer. In some embodiments, the tissue interface may further comprise a second layer of a permeable material, where the manifolding bubbles are formed as closed cells between the first layer and the second layer. The tissue interface may also include a third layer of liquid-impermeable material positioned adjacent to the second layer, where one or more fluid passageways may be formed between the second layer and third layer for delivering a therapeutic fluid to the tissue site.