Methods, systems, and apparatus, including computer programs encoded on computer-storage media, for escape detection and mitigation for aquaculture. In some implementations, a method includes obtaining one or more images that depict one or more fish within an enclosure; generating, as a result of providing the one or more images to multiple detection models, a value that reflects a quantity of fish that are depicted in the images that are likely a member of each different type of fish; detecting an error condition relating to a possible opening of the enclosure based at least on the value; and in response to detecting the error condition relating to the possible opening of the enclosure, initiating one or more mitigation actions relating to the possible opening.