The present invention relates to a milling machine processing system with an intelligently follow-up cutting fluid nozzle and a working method. The milling machine processing system comprises a workpiece stage, wherein a milling machine box body is arranged above the workpiece stage; a milling cutter mechanism is mounted on the milling machine box body for processing workpieces on the workpiece stage; a rotating mechanism is mounted on an end surface of the milling machine box body located at one side of a milling cutter; the rotating mechanism is connected with a two-axis linkage mechanism and drives the two-axis linkage mechanism to rotate about a center line on which the milling cutter is located; the two-axis linkage system is connected with a nozzle through an angle adjusting mechanism and is used for adjusting a position and an angle of the nozzle.