- 专利标题： Plasma autoantibody biomarkers for basal like breast cancer
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申请号： US16743906申请日： 2020-01-15
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公开(公告)号： US11525831B2公开(公告)日： 2022-12-13
- 发明人: Joshua LaBaer , Jie Wang , Ji Qui , Garrick Wallstrom , Karen Anderson , Jin Park , Jonine Figueroa
- 申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY , THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
- 申请人地址： US AZ Scottsdale; US MD Bethesda
- 专利权人： ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY,THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
- 当前专利权人： ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY,THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
- 当前专利权人地址： US AZ Scottsdale; US MD Bethesda
- 代理机构： Quarles & Brady, LLP
- 主分类号： G01N33/564
- IPC分类号： G01N33/564 ; G01N33/574 ; C07K16/30 ; C12Q1/6886 ; C12N15/11
摘要：
Cancer patients make antibodies to tumor-derived proteins that are potential biomarkers for early detection. Twenty-eight antigens have been identified as potential biomarkers for the early detection of basal-like breast cancer (Tables 1, 2). Also, a 13-AAb classifier has been developed that differentiate patients with BLBC from healthy controls with 33% sensitivity at 98% specificity (Table 3).
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