A cooperative fuzzy-neural control method is designed in this present invention. Due to the difficulty for cooperatively controlling the concentrations of the dissolved oxygen and nitrate nitrogen in wastewater treatment process, a cooperative fuzzy-neural control method is investigated. In this proposed method, firstly, a interval type-2 fuzzy neural network is employed to construct the cooperative fuzzy-neural controller. Secondly, a parameter cooperative strategy is proposed to cooperatively optimize the global and local parameters of the cooperative fuzzy-neural controller to meet the control requirements. This proposed cooperative fuzzy-neural control method can cooperatively control the concentrations of the dissolved oxygen and nitrate nitrogen in wastewater treatment process. The results illustrate that the proposed cooperative fuzzy-neural control method can achieve the high control accuracy and guarantee the normal operations of wastewater treatment process under the different operation conditions.