A method for measuring a seam on aircraft skin based on a large-scale point cloud is disclosed. A point cloud density of each point in an aircraft skin point cloud is calculated. Seam and non-seam point clouds are divided according to a discrepancy of the calculated point cloud density. A point is selected from the point cloud of the seam area, and a section at the point is extracted. A certain range of the seam and non-seam point clouds is projected to the section and a projected point cloud is acquired. A calculation model of flush and gap is constructed, and the flush and the gap of the aircraft skin seam at the measuring point is calculated according to the projected point cloud and the calculation model.