- 专利标题： Compositions and methods for modulating IL-10 immunostimulatory and anti-inflammatory properties
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申请号： US16414223申请日： 2019-05-16
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公开(公告)号： US11534480B2公开(公告)日： 2022-12-27
- 发明人: Demetri T. Moustakas , Mark N. Namchuk , Heather C. Losey , Juan C. Alvarez
- 申请人： Alkermes, Inc.
- 申请人地址： US MA Waltham
- 专利权人： Alkermes, Inc.
- 当前专利权人： Alkermes, Inc.
- 当前专利权人地址： US MA Waltham
- 代理机构： Lathrop GPM LLP
- 代理商 Michael Spellberg, Esq.
- 主分类号： A61K38/20
- IPC分类号： A61K38/20 ; C07K14/54
摘要：
The invention provides compositions and methods for modulating the immunostimulatory properties and/or anti-inflammatory properties of IL-10. The present invention provides scIL-10 polypeptides of Formula 1. The polypeptides of the invention are optionally linked to a fusion partner. The polypeptides of Formula 1 are referred to herein as “scIL-10” polypeptides and comprise an amino acid sequence arrangement from N-terminus to C-terminus in accordance with Formula 1: (first monomer subunit)-LINKER-(second monomer subunit) Formula 1 wherein the first monomer subunit, the second monomer subunit or both the first and second monomer subunits may be independently selected from: an unsubstituted IL-10 monomer subunit; or a substituted IL-10 monomer subunit comprising at least one amino acid substitution; and wherein LINKER is any amino acid linker of at least 1-100 amino acids in length.
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