A method and apparatus of prediction for video coding using MH (Multiple Hypothesis) mode are disclosed. According to this method, a block is partitioned into a first partition and a second partition. A first candidate and a second candidate are derived for the first and second partitions respectively. At least one of the first candidate and the second candidate is derived using a candidate list derived for a regular Merge mode (or also called as normal Merge mode). An MH prediction generated by blending a first prediction corresponding to a first candidate and a second prediction corresponding to a second candidate, and the MH prediction is applied to a part of the current block.