Invention Grant
- Patent Title: Prins reaction and compounds useful in the synthesis of halichondrin macrolides and analogs thereof
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Application No.: US16959882Application Date: 2019-01-03
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Publication No.: US11542269B2Publication Date: 2023-01-03
- Inventor: Hyeong-Wook Choi , Francis G. Fang
- Applicant: EISAI R&D MANAGEMENT CO., LTD.
- Applicant Address: JP Tokyo
- Assignee: EISAI R&D MANAGEMENT CO., LTD.
- Current Assignee: EISAI R&D MANAGEMENT CO., LTD.
- Current Assignee Address: JP Tokyo
- Agency: Clark & Elbing LLP
- International Application: PCT/US2019/012178 WO 20190103
- International Announcement: WO2019/136145 WO 20190711
- Main IPC: C07D493/22
- IPC: C07D493/22 ; C07D307/28 ; C07D493/04 ; C07D407/06 ; C07D407/14 ; A61P35/00
Abstract:
The invention provides methods utilizing Prins reaction in the preparation of compounds that may be useful as intermediates in the synthesis of halichondrin macrolides and analogs thereof. The invention also provides compounds that may be useful as intermediates in the synthesis of a halichondrin macrolides and methods for preparing the same.
Public/Granted literature
- US20200331928A1 PRINS REACTION AND COMPOUNDS USEFUL IN THE SYNTHESIS OF HALICHONDRIN MACROLIDES AND ANALOGS THEREOF Public/Granted day:2020-10-22
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