Invention Grant
- Patent Title: Carbonic anhydrase-catalyzed isotope equilibrium between CO2—H2O for oxygen isotope analyses of aqueous samples
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Application No.: US16667559Application Date: 2019-10-29
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Publication No.: US11543398B2Publication Date: 2023-01-03
- Inventor: Sang-Tae Kim , Nicolas Randazzo , Martin Knyf
- Applicant: McMaster University
- Applicant Address: CA Hamilton
- Assignee: McMaster University
- Current Assignee: McMaster University
- Current Assignee Address: CA Hamilton
- Agency: Bereskin & Parr LLP/S.E.N.C.R.L., s.r.l.
- Agent Sandra Marone
- Main IPC: G01N33/18
- IPC: G01N33/18 ; H01J49/30
Abstract:
The present application relates to a method for improving analytical efficiency and cost effectiveness of oxygen isotope analysis of an aqueous sample. In particular, the present application relates to a method of determining an oxygen isotope composition of an aqueous sample by (a) equilibrating the aqueous sample with CO2 gas wherein the aqueous sample comprises an effective amount of carbonic anhydrase (CA) enzyme; and (b) measuring the oxygen isotope composition of the CO2 at equilibrium, wherein the oxygen isotope composition of the CO2 corresponds to the oxygen isotope composition of the aqueous sample.
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