Invention Grant
- Patent Title: Bicyclic thiazine and oxazine derivatives as beta-secretase inhibitors and methods of use
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Application No.: US16466202Application Date: 2017-12-13
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Publication No.: US11548903B2Publication Date: 2023-01-10
- Inventor: Jennifer R. Allen , Matthew P. Bourbeau , Ning Chen , Qingyian Liu , Liping H. Pettus , Aaron C. Siegmund
- Applicant: AMGEN INC.
- Applicant Address: US CA Thousand Oaks
- Assignee: AMGEN INC.
- Current Assignee: AMGEN INC.
- Current Assignee Address: US CA Thousand Oaks
- Agent Markus Bergauer
- International Application: PCT/US2017/066180 WO 20171213
- International Announcement: WO2018/112084 WO 20180621
- Main IPC: C07D513/04
- IPC: C07D513/04 ; C07D498/04 ; A61P25/28

Abstract:
The present disclosure provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula (I): (Formula (I)) wherein variables X, Y, R2, R3, R4, R5, R6, and n of Formula (I) are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, and uses of the compounds and compositions for treatment of disorders and/or conditions related to Aβ plaque formation and deposition, resulting from the biological activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's disease, cognitive deficits, cognitive impairments, and other central nervous system conditions.
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