- Patent Title: Isoxazole derivatives as FXR agonists and methods of use thereof
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Application No.: US16871551Application Date: 2020-05-11
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Publication No.: US11555032B2Publication Date: 2023-01-17
- Inventor: Guoqiang Wang , Jun Ma , Bin Wang , Ruichao Shen , Xuechao Xing , Yong He , Yat Sun Or
- Applicant: Enanta Pharmaceuticals, Inc.
- Applicant Address: US MA Watertown
- Assignee: Enanta Pharmaceuticals, Inc.
- Current Assignee: Enanta Pharmaceuticals, Inc.
- Current Assignee Address: US MA Watertown
- Agency: Elmore Patent Law Group, P.C.
- Agent Edgar W. Harlan; Carolyn S. Elmore
- Main IPC: C07D417/12
- IPC: C07D417/12 ; C07D413/12 ; C07D417/14 ; C07D261/08 ; C07D413/14
Abstract:
The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts and esters thereof: pharmaceutical compositions comprising these compounds and methods of using these compounds to treat or prevent a disease or disorder mediated as FXR modulators. Specifically, the present invention relates to isoxazole derivatives useful as agonists for FXR, and methods for their preparation and use.
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