Invention Grant
- Patent Title: Purine diones as Wnt pathway modulators
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Application No.: US17100474Application Date: 2020-11-20
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Publication No.: US11555037B2Publication Date: 2023-01-17
- Inventor: Soo Yei Ho , Stephanie Eliane Blanchard , Athisayamani Jeyaraj Duraiswamy , Jenefer Alam , Vikrant Arun Adsool
- Applicant: Agency for Science, Technology and Research
- Applicant Address: SG Singapore
- Assignee: Agency for Science, Technology and Research
- Current Assignee: Agency for Science, Technology and Research
- Current Assignee Address: SG Singapore
- Agency: Foley & Lardner LLP
- Priority: GB1309333 20130523
- Main IPC: C07D473/06
- IPC: C07D473/06 ; A61K31/522 ; A61K31/5377 ; C07D473/08

Abstract:
The invention relates to the use of compounds of general structure (I) in modulation of the Wnt pathway wherein R1, R2, R3, R4 and R5 are each, independently, H or an alkyl group; D is selected from the group consisting of H, halogen, alkyl, cycloalkyl, aryl, and dialkylamino, each (other than H and halogen) being optionally substituted; Ar is an aryl or heteroaryl group, optionally substituted; Cy is an aryl, heteroaryl or a saturated ring containing at least one heteroatom, each being optionally substituted; and n is an integer from 1 to 3.
Public/Granted literature
- US20210155623A1 PURINE DIONES AS WNT PATHWAY MODULATORS Public/Granted day:2021-05-27
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