- 专利标题: Single wall nanotube constructs and uses thereof
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申请号: US16564322申请日: 2019-09-09
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公开(公告)号: US11564988B2公开(公告)日: 2023-01-31
- 发明人: David A. Scheinberg , Michael R. McDevitt , Christophe Antczak , Debjit Chattopadhyay , Rena May , Jon Njardarson , Mark Reid Phillips
- 申请人: David A. Scheinberg , Michael R. McDevitt , Christophe Antczak , Debjit Chattopadhyay , Rena May , Jon Njardarson , Mark Reid Phillips
- 申请人地址: US NY New York; US NY New York; US MA Arlington; US NJ Pennington; US MD Baltimore; US AZ Tucson; US NY New York
- 专利权人: David A. Scheinberg,Michael R. McDevitt,Christophe Antczak,Debjit Chattopadhyay,Rena May,Jon Njardarson,Mark Reid Phillips
- 当前专利权人: David A. Scheinberg,Michael R. McDevitt,Christophe Antczak,Debjit Chattopadhyay,Rena May,Jon Njardarson,Mark Reid Phillips
- 当前专利权人地址: US NY New York; US NY New York; US MA Arlington; US NJ Pennington; US MD Baltimore; US AZ Tucson; US NY New York
- 代理商 Benjamin Aaron Adler
- 主分类号: A61K47/52
- IPC分类号: A61K47/52 ; A61K39/385 ; A61K47/64 ; A61K47/65 ; A61K51/12 ; B82Y30/00 ; B82Y40/00 ; C01B32/174 ; A61K47/69 ; C01B32/176 ; B82Y5/00
摘要:
The present invention provides soluble single wall nanotube (SWNT) constructs functionalized with a plurality of a targeting moiety and a plurality of one or more payload molecules attached thereto. The targeting moiety and the payload molecules may be attached to the soluble SWNT via a DNA or other oligomer platform attached to the SWNT. These soluble SWNT constructs may comprise a radionuclide or contrast agent and as such are effective as diagnostic and therapeutic agents. Methods provided herein are to diagnosing or locating a cancer, treating a cancer, eliciting an immune response against a cancer or delivering an anticancer drug in situ via an enzymatic nanofactory using the soluble SWNT constructs.
公开/授权文献
- US20200061196A1 Single Wall Nanotube Constructs and Uses Thereof 公开/授权日:2020-02-27