Invention Grant
- Patent Title: Tm-enhanced blocking oligonucleotides and baits for improved target enrichment and reduced off-target selection
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Application No.: US15294695Application Date: 2016-10-15
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Publication No.: US11566282B2Publication Date: 2023-01-31
- Inventor: Mark Aaron Behlke , John Robert Havens , Mirna Jarosz , Zachary Zwirko , Doron Lipson , Frank Soo Juhn
- Applicant: Integrated DNA Technologies, Inc. , Foundation Medicine, Inc.
- Applicant Address: US IA Coralville; US MA Cambridge
- Assignee: Integrated DNA Technologies, Inc.,Foundation Medicine, Inc.
- Current Assignee: Integrated DNA Technologies, Inc.,Foundation Medicine, Inc.
- Current Assignee Address: US IA Coralville; US MA Cambridge
- Agency: Klintworth & Rozenblat IP LLP
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; C12Q1/6874 ; C12Q1/6869 ; C12Q1/6886 ; C12N15/10 ; C12Q1/6876
Abstract:
The invention is directed to modified oligonucleotide compositions and methods for selectively reducing unwanted nucleic acid contaminants and enriching for desired nucleic acid targets from complex genomic nucleic acid mixtures for sequencing applications. The modified oligonucleotide compositions include one or more modified groups that increase the Tm of the resultant oligonucleotide composition.
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