A display panel driving system includes: a display panel having a first panel partition and a second panel partition; a first display driving circuit operatively connected to the first panel partition and configured to drive the first panel partition; a second display driving circuit operatively connected to the second panel partition and configured to drive the second panel partition; and a comparison circuit respectively connected to the first and second display driving circuits; each display driving circuit is utilized to collect brightness level statistics associated with the display panel partitions it drives; each display driving circuit is configured to determine a cathode voltage value associated with the display panel partition it drives and transmit the cathode voltage value to the comparison circuit for comparison for each of the panel partitions and determine a target value which is then utilized to adjust the cathode voltage of the whole display panel.