A camera may use a multi-axis image sensor shifting system to implement both autofocus (AF) and optical image stabilization (OSI) functions. The multi-axis image sensor shifting system may include a flexure suspension arrangement and an actuator. The flexure suspension arrangement may include an inner frame, an intermediate frame, and an outer frame. The actuator may include one or more magnets, and two sets of one or more coils attached respectively to some of the frames of the flexure suspension arrangement. Current flowing through the coils may be regulated to interact with the magnetic field of the magnets to generate motive force to move an image sensor of the camera relative to a lens group in multiple directions.