Invention Grant
- Patent Title: Oligonucleotide encoded chemical libraries
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Application No.: US17236283Application Date: 2021-04-21
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Publication No.: US11577249B2Publication Date: 2023-02-14
- Inventor: Kandaswamy Vijayan , Andrew Boyd MacConnell , Joseph Franklin Rokicki
- Applicant: Plexium, Inc.
- Applicant Address: US CA San Diego
- Assignee: Plexium, Inc.
- Current Assignee: Plexium, Inc.
- Current Assignee Address: US CA San Diego
- Agency: Sheppard Mullin Richter & Hampton LLP
- Main IPC: C40B30/06
- IPC: C40B30/06 ; B01L3/00 ; C12N15/10 ; C12Q1/6869 ; C40B50/04 ; C40B50/14 ; C12Q1/6876 ; C40B50/16 ; C40B30/04

Abstract:
This application provides a bead with a covalently attached chemical compound and a covalently attached DNA barcode and methods for using such beads. The bead has many substantially identical copies of the chemical compound and many substantially identical copies of the DNA barcode. The compound consists of one or more chemical monomers, where the DNA barcode takes the form of barcode modules, where each module corresponds to and allows identification of a corresponding chemical monomer. The nucleic acid barcode can have a concatenated structure or an orthogonal structure. Provided are method for sequencing the bead-bound nucleic acid barcode, for cleaving the compound from the bead, and for assessing biological activity of the released compound.
Public/Granted literature
- US20210394178A1 OLIGONUCLEOTIDE ENCODED CHEMICAL LIBRARIES Public/Granted day:2021-12-23
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