Provided are a method and device for transmitting and receiving a signal in a wireless communication system. In a wireless communication system according to an embodiment of the present disclosure, a radio unit (RU) is configured to obtain channel information about a plurality of reception paths of the RU, through which signals of at least one user equipment (UE) are received, with respect to each UE, determine a combined weight based on the channel information by using preset mapping information according to the number of the plurality of reception paths and the number of combined paths that are combined from the plurality of reception paths, and transmit a combined signal to a digital unit (DU) through the combined paths, the combined signal being generated as a result of combining the signals received through the plurality of reception paths according to the determined combined weight.