An example method for managing a memory device includes a non-volatile memory. The example method further includes providing a first time-stamp to the memory device, wherein the first time-stamp is a power-down time-stamp of the memory device, storing the first time-stamp, associating the first time-stamp with at least one region of the non-volatile memory, providing a second time-stamp to the memory device, wherein the second time-stamp is a subsequent power-up time-stamp of the memory device, associating the second time-stamp with the at least one region of the non-volatile memory, determining a difference time between the first time-stamp and the second time-stamp, and, based on the difference time, performing a refresh operation of the at least one region of the non-volatile memory. Further, a related memory device is disclosed, as well as a method for measuring the off-time of a memory device.