Systems and methods for monitoring for an occlusion in an aspiration line during an ophthalmic surgical procedure. An ophthalmic surgical system may include a first aspiration pump located in a handpiece, a second aspiration pump located away from the handpiece such as in a console, and a pressure sensor located between the first aspiration pump and the second aspiration pump. The pressure sensor is adapted to monitor for an occlusion in the aspiration line upstream of the first aspiration pump. The second aspiration pump may be operated at the same flow rate as the first aspiration pump and/or to maintain a constant pressure between the second aspiration pump and the first aspiration pump. Systems and methods as disclosed allow for a handpiece pump located close to the working tip while providing reliable occlusion detection with a pressure sensor located away from the handpiece.