- 专利标题： Antibodies binding to VISTA at acidic pH
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申请号： US16493712申请日： 2018-03-13
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公开(公告)号： US11603406B2公开(公告)日： 2023-03-14
- 发明人: Robert J. Johnston , Arvind Rajpal , Paul O. Sheppard , Luis Borges , Andrew Rankin , Keith Sadoon Bahjat , Alan J. Korman , Andy X. Deng , Lin Hui Su , Ginger Rakestraw
- 申请人： Five Prime Therapeutics, Inc. , Bristol-Myers Squibb Company
- 申请人地址： US CA South San Francisco; US NJ Princeton
- 专利权人： Five Prime Therapeutics, Inc.,Bristol-Myers Squibb Company
- 当前专利权人： Five Prime Therapeutics, Inc.,Bristol-Myers Squibb Company
- 当前专利权人地址： US CA South San Francisco; US NJ Princeton
- 代理机构： McNeill Baur PLLC
- 国际申请： PCT/US2018/022230 WO 20180313
- 国际公布： WO2018/169993 WO 20180920
- 主分类号： C07K16/28
- IPC分类号： C07K16/28
摘要：
The present application relates to antibodies specifically binding to the V-domain immunoglobulin-containing suppressor of T-cell activation (VISTA) at acidic pH and their use in cancer treatment. In some embodiments, the antibodies bind specifically to human VISTA at acidic pH, but do not significantly bind to human VISTA at neutral or physiological pH.
公开/授权文献
- US20200055936A1 Antibodies Binding to VISTA at Acidic pH 公开/授权日：2020-02-20
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