Invention Grant
- Patent Title: Antibodies binding to VISTA at acidic pH
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Application No.: US16493712Application Date: 2018-03-13
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Publication No.: US11603406B2Publication Date: 2023-03-14
- Inventor: Robert J. Johnston , Arvind Rajpal , Paul O. Sheppard , Luis Borges , Andrew Rankin , Keith Sadoon Bahjat , Alan J. Korman , Andy X. Deng , Lin Hui Su , Ginger Rakestraw
- Applicant: Five Prime Therapeutics, Inc. , Bristol-Myers Squibb Company
- Applicant Address: US CA South San Francisco; US NJ Princeton
- Assignee: Five Prime Therapeutics, Inc.,Bristol-Myers Squibb Company
- Current Assignee: Five Prime Therapeutics, Inc.,Bristol-Myers Squibb Company
- Current Assignee Address: US CA South San Francisco; US NJ Princeton
- Agency: McNeill Baur PLLC
- International Application: PCT/US2018/022230 WO 20180313
- International Announcement: WO2018/169993 WO 20180920
- Main IPC: C07K16/28
- IPC: C07K16/28
Abstract:
The present application relates to antibodies specifically binding to the V-domain immunoglobulin-containing suppressor of T-cell activation (VISTA) at acidic pH and their use in cancer treatment. In some embodiments, the antibodies bind specifically to human VISTA at acidic pH, but do not significantly bind to human VISTA at neutral or physiological pH.
Public/Granted literature
- US20200055936A1 Antibodies Binding to VISTA at Acidic pH Public/Granted day:2020-02-20
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