A header for a crop harvesting machine includes front and rear wheel arrangements that pivot about respective upright axis between a field orientation and a perpendicular transport orientation, while having respective suspensions arrangements movable between different suspended heights. A biasing spring provides lift assist to carry weight of the wheel arrangement during adjustment of the suspension elevation while being isolated from the suspension once set at any one elevation. The front wheel arrangement includes an anti-rotation latch that locks the front wheel in the field orientation automatically upon disconnection of a hitch arm. A second wheel of the rear wheel arrangement can be held in a raised position relative to a first wheel in a field orientation. Load bearing surfaces between the suspended rear wheels and the header frame abut one another when latching to the header frame to isolate the suspension from the header frame in the transport orientation.