A multi-camera positioning and dispatching system includes a plurality of cameras and processing device. The cameras are disturbed over an indoor space having a plurality of areas; the cameras are corresponding to the areas and capture the images of the areas respectively. The processing device converts the pixel coordinates of the image of the camera corresponding to each area into the camera coordinates of the area, and converts the cameras coordinates of the area into the world coordinates of the area so as to integrate the images with one another and obtain a panoramic map, defined by a world coordinate system, of the indoor space. The processing device projects the working unit in the image captured by any one of the cameras to the panoramic map. The system can achieve positioning function via the panoramic map so as to optimize indoor environment management and save manpower.