- 专利标题： Compounds for the treatment of BRAF-associated diseases and disorders
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申请号： US17745346申请日： 2022-05-16
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公开(公告)号： US11634409B2公开(公告)日： 2023-04-25
- 发明人: Patrick Michael Barbour , Katie Keaton Brown , Adam Wade Cook , Erik James Hicken , Dean Russell Kahn , Ellen Ruth Laird , Andrew Terrance Metcalf , David Austin Moreno , Bradley Jon Newhouse , Spencer Phillip Pajk , Brett Joseph Prigaro , Li Ren , Eugene Tarlton
- 申请人： Array BioPharma Inc.
- 申请人地址： US CO Boulder
- 专利权人： Array BioPharma Inc.
- 当前专利权人： Array BioPharma Inc.
- 当前专利权人地址： US CO Boulder
- 代理商 Zhigang Rao
- 主分类号： C07D403/12
- IPC分类号： C07D403/12 ; C07D239/90 ; C07D239/91 ; A61K31/4184 ; A61K45/06
摘要：
Provided herein are compounds of the Formula I: and pharmaceutically acceptable salts, solvates and polymorphs thereof, wherein L, X1, R1, R2, R3, R4, R5 and R6 are as defined herein, for the treatment of BRAF-associated diseases and disorders, including BRAF-associated tumors, including malignant and benign BRAF-associated tumors of the CNS and malignant extracranial BRAF-associated tumors.
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