Disclosed are a signal transmission and reception method and device in a wireless communication system. A method for receiving a signal by a terminal in a wireless communication system according to an embodiment of the present specification comprises the steps of: receiving configuration relating to a signal which is down-converted in frequency on the basis of an O/E converter; and receiving the signal in a particular resource region on the basis of the configuration. A frequency domain of the particular resource region comprises a plurality of chunks. The chunks comprise at least one component carrier (CC). The configuration comprises information indicating a main chunk relating to differential phase shift keying (DPSK). The transmission of the signal is on the basis of the DPSK applied between the chunks in the frequency domain with respect to the main chunk.