Systems and methods to facilitate adjusting content to facilitate therapeutic outcomes of subjects are disclosed. Exemplary implementations may: obtain subject information related to subject, the subject information characterizing (i) physiological health of the subject, (ii) a psychological profile of the subject defined by parameter values of psychological parameters, and (iii) a therapeutic outcome for the subject to achieve; effectuate, via a client computing platform associated with a caregiver of the subject, presentation of a caregiver interface that presents the subject information and enables the caregiver to provide caregiver input, wherein the caregiver input causes adjustments to (i) content presented to the subject within a game and (ii) an engagement level of the content, wherein the content facilitates achievement of the therapeutic outcome by the subject; and effectuate, based on the caregiver input, presentation of the adjustments to the content via a client computing platform associated with the subject.