Invention Grant
![Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors](/docs/US/2023-05-16/US11648243B2/abs.jpg.600x600.jpg)
- Patent Title: Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors
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Application No.: US17108528Application Date: 2020-12-01
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Publication No.: US11648243B2Publication Date: 2023-05-16
- Inventor: Steven W. Andrews , Sean Aronow , James F. Blake , Barbara J. Brandhuber , James Collier , Adam Cook , Julia Haas , Yutong Jiang , Gabrielle R. Kolakowski , Elizabeth A. Mcfaddin , Megan L. Mckenney , Oren T. McNulty , Andrew T. Metcalf , David A. Moreno , Ginelle A. Ramann , Tony P. Tang , Li Ren , Shane M. Walls
- Applicant: Array Biopharma Inc.
- Applicant Address: US CO Boulder
- Assignee: Array Biopharma Inc.
- Current Assignee: Array Biopharma Inc.
- Current Assignee Address: US CO Boulder
- Agent Bradley W. Crawford
- Main IPC: A61K31/4545
- IPC: A61K31/4545 ; A61K31/4162 ; C07D471/04 ; A61P1/00 ; A61P35/00 ; A61P35/02 ; A61K31/444 ; A61K31/497 ; A61K31/501 ; A61K31/506 ; A61K31/5377 ; A61K45/06 ; A61P1/12
![Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors](/abs-image/US/2023/05/16/US11648243B2/abs.jpg.150x150.jpg)
Abstract:
Provided herein are compounds of the Formula I:
or pharmaceutically acceptable salt or solvate thereof, wherein A, B, X1, X2, X3, X4, Ring D, E, Ra, Rb, n and m have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.
or pharmaceutically acceptable salt or solvate thereof, wherein A, B, X1, X2, X3, X4, Ring D, E, Ra, Rb, n and m have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.
Public/Granted literature
- US20220313676A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS Public/Granted day:2022-10-06
Information query
IPC分类:
