A disc brake (1) for motor vehicles includes at least two brake pads (25, 26), an application unit (4) with a setting spindle (5) arranged axially in the direction of the brake pads (25, 26), and a resetting device (7) for central adjustment of the setting spindle (5) after reaching a degree of wear of the brake pads (25, 26). The resetting device (7) has a housing (8), a sensor (9), a resetting shaft (10), and an adapter (11) with a decentral output (12). In one example, the adapter (11) has a cover (13) and a chain drive (14) for to transmitting an actuating movement from the decentral output (12) to the resetting shaft (10).