Wearable devices and methods for preventing and treating carpal tunnel syndrome or DeQuervain's syndrome. The wearable device may include a wrist contact portion for receiving a user's forearm, a stretching mechanism configured to apply opposing forces to a first contact portion and a second contact portion to stretch the user's underlying tissue, the first and second contact portions configured to contact the user's forearm, and one or more straps configured to adjust the compressive force being applied to the user's forearm by the first and second contact portions. The first contact portion may be configured to apply a compressive force to the user's forearm at a first location. The second contact portion may be configured to apply a compressive force to the user's forearm at a second location different than the first location.