Invention Grant
- Patent Title: Basecaller with dilated convolutional neural network
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Application No.: US16899545Application Date: 2020-06-11
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Publication No.: US11664090B2Publication Date: 2023-05-30
- Inventor: Yong Chu , Stephanie Jo Schneider , Rylan Schaeffer , David Woo
- Applicant: Life Technologies Corporation
- Applicant Address: US CA Carlsbad
- Assignee: Life Technologies Corporation
- Current Assignee: Life Technologies Corporation
- Current Assignee Address: US CA Carlsbad
- Agency: Mauriel Kapouytian Woods LLP
- Agent Elaine K. Lee; Michael Mauriel
- Main IPC: G06K9/62
- IPC: G06K9/62 ; G16B30/00 ; G16B40/00 ; G16B25/00 ; C12Q1/6869 ; G06N3/084 ; G06N5/046

Abstract:
A method of automatically sequencing or basecalling one or more DNA (deoxyribonucleic acid) molecules of a biological sample is described. The method comprises using a capillary electrophoresis genetic analyzer to measure the biological sample to obtain at least one input trace comprising digital data corresponding to fluorescence values for a plurality of scans. Scan labelling probabilities for the plurality of scans are generated using a trained artificial neural network comprising a plurality of layers including convolutional layers. A basecall sequence comprising a plurality of basecalls for the one or more DNA molecules based on the scan labelling probabilities for the plurality of scans is determined.
Public/Granted literature
- US20210398615A1 BASECALLER WITH DILATED CONVOLUTIONAL NEURAL NETWORK Public/Granted day:2021-12-23
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