This disclosure relates generally to wireless communications and, more particularly, to systems and methods for uplink signaling using blind channel estimation at a base station. In one embodiment, a method performed by a communication device, includes: associating a time slot with a data packet comprising a head portion and a tail portion, wherein the head portion comprises a communication device identifier and the tail portion comprises user data associated with the head portion; spreading the head portion into a first predetermined transmission format; spreading the tail portion into a second predetermined transmission format; and transmitting the spreaded head portion with the spreaded tail portion to a communication node, wherein the spreaded head portion comprises information to be used by the communication node for channel estimation and for decoding the tail portion to retrieve the user data.