Systems, apparatuses, and methods related to three tiered hierarchical memory systems are described herein. A three tiered hierarchical memory system can leverage persistent memory to store data that is generally stored in a non-persistent memory, thereby increasing an amount of storage space allocated to a computing system at a lower cost than approaches that rely solely on non-persistent memory. An example apparatus may include a persistent memory, and one or more non-persistent memories configured to map an address associated with an input/output (I/O) device to an address in logic circuitry prior to the apparatus receiving a request from the I/O device to access data stored in the persistent memory, and map the address associated with the I/O device to an address in a non-persistent memory subsequent to the apparatus receiving the request and accessing the data.